Ten years ago, psycho killer Charles "Chucky" Lee Ray was gunned down by the law. Using voodoo magic he transfers his soul into the nearest available body, this being a doll! His only hope of escape? Finding a human body to exchange souls with. The world’s most notorious doll finally meets his match – in his ex-girlfriend Tiffany (Jennifer Tilly). On a dark and stormy night, with marriage on her mind she rescues Chucky’s remains and breathes life back into the little "guy". Faster than she can say "I will," Tiffany gets the white gown she’s always dreamed of, it’s just a whole lot smaller than she expected. But then, so is she. For better or worse, Chucky and Tiffany will be a matched set if they ever get back into human bodies. In their search for a couple of compatible body donors they meet teenage newlyweds Jesse (Nick Stabile) and Jade (Katherine Heigl), two young lovers-on-the-run who become unwitting accomplices. The wedding party hits the highway and what ensues is a road trip filled with murder, music and mayhem.