A heroine for the modern age, district nurse Frankie Maddox (Eve Myles) looks life and death in the eye on a daily basis; her mission is to make a difference. She cares about her patients and their families but never turns into a busybody, knowing that, at the end, what everyone wants is a calm friend who is on the side of the patient. Heart-warming and funny, the series follows Frankie and her eclectic team as they visit their patients at home, and takes a look at ordinary lives which are often in huge domestic crises. The nurses enjoy their work, it may infuriate, frustrate and even bore them at times, but they turn up day in and day out and wouldn't choose to do anything else - even when missed birthday parties and emotionally neglected kids are the order of the day. All that matters, whatever their flaws, is that they do a good day's work, and make life better for their patients.