College is usually the most rocking and memorable time of most people's lives. The same holds true for our three heroes Amar (Riteish Deshmukh), Meet (Vivek Oberoi) and Prem (Aftab Shivdasani). Their last day of graduation marked the first day of Robert D Souza as the new Principal. Under his regime, it was a taboo to even look at a girl, let alone engage in any other sexual activity. When we meet our three heroes 6 years later, we see that the shackles of married life have dulled their edges and they are extremely unhappy in their respective marriages due to various reasons. Sexually as well as emotionally frustrated, they get a golden opportunity to revisit their glory days when they are invited for a College Reunion . Leaving their wives behind, they embark on a journey of Grand Masti, for a crazy and promiscuous time, where they will relive their college life by scoring with girls and adding some spice to their bland lives. Their joy is short lived when they realize that the University is still under the strict and dangerous regime of Principal Robert D Souza. In spite of the Principal s terror, they meet three women, Rose - a hot teacher, Mary - a sexy student and Marlow - a gorgeous ex-student. Here on wards it s a fun roller coaster ride! How the three heroes juggle their respective wives, Rose, Mary, Marlow and a blood thirsty Principal Robert in the midst of the Reunion celebrations leading to hilarious moments.