Hollywood Vampyr tells the tale of the young female vampire Fatal (Nora Zimmett), a former heroin addict, who has embraced the underground gothic sub-culture. She decides to leave the "family" and break free from their depraved world with the help of her college tutor Tom (Jeff Marchelletta). Standing in the way is Blood (Trevor Goddard), the dominant coven leader whom she is unwillingly bound to. Against Professor Fulton`s (Muse Watson), warnings, Tom finds Fatal`s world increasingly seductive. As Fatal gradually loses the only person she trusts, she suddenly discovers destiny has other wicked plans.