After being proclaimed queen of Castile in Segovia to the death of his brother King Henry IV of Castile , Isabel will have to win with her husband Ferdinand of Aragon loyalty and support of the nobles to consolidate his reign. However, a group of nobles opposed to it will defend the inheritance of Joan , known as the Beltraneja . To do this , they go to Portugal, whose king , Alfonso V , they established an alliance and declare war on Elizabethan side . Begins what is known as the War of Succession Castellana.Tras her, Isabel and Fernando , as kings of Castile and Aragon , they embark on the War of Granada , who for ten years have occupied the military efforts of the kingdom. The goal is to conquer - conquer , from the standpoint of the Castilian - Nazari Kingdom . Meanwhile, the Inquisition was established, progressively cornered Jews and the trip to the East Indies proposing a sailor named Christopher Columbus is prepared. If on his way to the throne , they met a determined but sweet young Isabel , the exercise of power and personal suffering , converted to Isabel in that ruling with its lights and shadows is one of the greatest characters in the history of Spain and a woman with a personality hardly imitable .