Josie (Rachael Leigh Cook), Melody (Tara Reid) and Val (Rosario Dawson) are life-long friends determined to take their band out of the garage and into the stratosphere - while staying true to their own look, style and sound. The band is soon discovered by hot-shot manager Wyatt Frame (Alan Cumming) who introduces them to MegaRecords CEO Fiona (Parker Posey) as the next best thing. Within days they have the number one single in the country, but they soon discover that all is not what it seems. Fiona and Wyatt have devised a hi-tech plan to control the youth of America through their music. It's time for Josie and the Pussycats to bare their claws and fight back.