A full moon hangs above a Hawaiian island as passengers board a plane for LA. Among them are two people suffering from an unexplainable infection. They die on the flight but not before infecting other passengers. Dr. Haines, a coroner, is also on board and has suspicions as to what is going on. The pilot puts him through to Dr. Laura Chadwick from the Centre for Disease Control and a team from the National Security Agency, who are now in a race against time to bring the passengers home before they all die. As the flight approaches the Californian coast, the full moon hangs above the fated plane. Facing death, the surviving passengers are left in terror fearing...a Killing Moon!