Set during World War II, Lost in Yonkers tells the story of two brothers who are sent to live with their domineering grandmother after their mother's death. Strong as steel and twice as cold, Grandma Kurnitz (Irene Worth) rules her roost with an iron fist. And caught in her grasp is the boys' lovely Aunt Bella (Ruehl), who has the mind of a child and the dreams of a woman. But when Uncle Louie (Dreyfuss), a small-time gangster with plenty of "moxie" arrives, everyone gets a surprising second chance at happiness. Worth and Ruehl both won Tony Awards for their stage performances, and Dreyfuss adds a scene-stealing turn as Louie.