Beeing a teen is tough enough for Kathy Cauldwell (Scarlett Johansson) without having to be the target of her little brother George's constant practical jokes. But life really gets crazy when Dad (Judge Reinhold) and Mom leave for France and George is magically transformed into a pig via some ancient rocks belonging to their nanny Matilda (Eva Mendes). Only Matilda's Mexican Grandmother's voodoo can break the spell, and Kathy, Matilda, George the Pig, and George's friend Freud (Alex D. Linz) take off on a madcap adventure south of the border to find her. But things go from bad to worse when George is pignapped by the local butcher. Now, the race is on for the group to save George from becoming bacon, turn him back into a boy, and get back home before their unsuspecting parents return.