In a city that keeps surviving disaster, one elite team is dedicated to making our shores a little safer. Dwayne Cassius "King" Pride (Scott Bakula) knows every corner of the Crescent City from his days as a deputy. Now, his mission has higher stakes as he leads an elite crew that tackles crimes that threaten national security. The Big Easy is in good hands with a supremely professional team with a passion for justice. Pride's trusted right-hand man Christopher Lasalle (Lucas Black) loves this city like few others. Newcomer Meredith Brody (Zoe McLellan) unleashes her unique skills in interrogation to corner the crooks. Eccentric forensic scientist Sebastian Lund (Rob Kerkovich) tackles the evidence with high-tech tactics while Medical Examiner Loretta Wade (CCH Pounder) employs her wisdom and experience to reveal the secrets of the dead. Together, they can counter any threat, from escaped prisoners, to bio-threats, to unrepentant killers.