Frankie Paige (Patricia Arquette) has absolutely no faith in God. All of that changes when she suddenly begins to suffer the stigmata - the living wounds of the crucified Christ. Frankie's miraculous bleeding comes to the attention of the Vatican's top investigator, Father Kiernan (Gabriel Byrne). But when Cardinal Houseman (Jonathan Pryce) discovers that Frankie is actually channeling an extraordinary and provocative message that could destroy the Church, he's convinced that she - and the force possessing her - must be forever silenced. Determined to stop this deadly conspiracy, Kiernan risks his faith - and his life - to save her and the message that will change the destiny of mankind forever.