The friends and housemates of the hit show are back for a brand new chapter in their lives and now things are very different for them all. With Rex moving into Apartment 6 and her return to the surgical programme, Alex thought she had it all - a great home life, work life and love life, but then her supervisor humiliates her during an operation and she begins to question all three aspects of her life. A chance encounter with a woman asking for money at a tram stop makes Kelly think about her priorities. What should her life really be about? Richie is becoming the voice of Melbourne, selling insurance and holidays in New Zealand. The work's light and the money is good, but is he selling his soul? Meanwhile Evan meets an old back packer friend and invites him to stay for a few days. Kelly gets a bad vibe from him and can't work out why, until she spends one night alone in the flat with him. Miranda discovers that a major casting agent isn't recommending her for jobs and seeks to find out why. Sometimes asking for the truth is a dangerous exercise. Will she move to the USA to live her dream now she has a Green Card, and if so, what about Chloe?