It is the 1970s and Firmino Santos Guerra is abandoned by his fiancee, Filomena , in favour of his greatest enemy, Borges Capadocio. From this day on bad blood runs between the two families. Thirty years later and Borges Capadocio and his two sons are brutally murdered leaving behind his widow, Filomena. She enlists the help of her three daughters - all called Maria - who are each given the task of finding an assassin in order to wreak revenge on the Santos Guerra family. Maria Francisca , the eldest, has to find a gunman known as Ze das Cobras, who has not spoken to a woman since the death of his mother. Maria Rosa searches for Chief Tenorio, an honest backwoods cop, who also happens to be an expert on knives. Maria Pia , the youngest, goes off in search of Jesuino Cruz, the most feared killer in the region, but the problem is he's in jail. Destiny, however, has different plans for The Three Marias as their quests take them in unexpected directions.