A police investigation into the murder of high school student Tomie Kawakami uncovers a history of mysterious deaths of girls with the same name going back to the 1860s. Detective Harada tracks down a classmate of Tomie named Tsukiko, an art student, who is being treated for amnesia. She has no memory of the 3 month period around Tomie's death, and is starting to suspect the cause might be supernatural. Meanwhile, Tsukiko's new neighbor, her former high school teacher, Yamamoto is rearing a peculiar baby-like creature. Over the span of a few weeks it grows into a beautiful teenage girl with orange eyes and responding to the name Tomie Kawakami. And Tomie will not die.