A small group of survivors take refuge in an empty hospital with plans on re-building. They rescue a young girl who is the victim of a brutal attack, but soon discover that they were followed by a savage band of cannibals known as Rovers, led by Jackal (Michael Madsen). The Rovers begin to take them just one at a time (because live meat keeps fresher for longer). As the survivors numbers dwindle, they are faced with a stark choice. Do they run and hide, or do they stay and fight tooth and nail?