A police investigation into the murder of high school student Tomie Kawakami (Miho Kanno) uncovers a history of mysterious deaths of girls with the same name going back to the 1860's. Detective Harada (Tomorô Taguchi) tracks down a classmate of Tomie named Tsukiko (Mami Nakamura), an art student, who is being treated for amnesia. She has no memory of the 3 month period around Tomie's death, and is starting to suspect the cause might be supernatural. Meanwhile, Tsukiko's new neighbor, her former high school teacher, Yamamoto (Kenji Mizuhashi) is rearing a peculiar baby-like creature. Over the span of a few weeks it grows into a beautiful teenage girl with orange eyes and responding to the name Tomie Kawakami. And Tomie will not die.
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