In it's 12th and final year, the newly formed Medical Response Unit (MRU) takes centre stage treating patients at the site of accidents and then bringing them to the Emergency Department for continued medical care. The MRU, led by Mike Vlasek (John Waters), is on the front line of a vast range of medical disasters, including an explosion at a winery and a devastating bus crash. The year starts with the ED team dealing with the shocking aftermath of the news of Erica's death. Bart and Amy continue to be at logger-heads until Bart's wise counsel to a troubled patient results in them starting a secret love affair. Steve joins the MRU and is confronted with demons from his past. Gabrielle (Virginia Gay) must deal with her father's heart attack and new paramedic Jo (Mirrah Foulkes) learns whether she has Huntington's disease. Frank (John Howard) continues to fiercely protect his team, and starts the new intern program. The series ends with the ED and MRU teams sharing an emotional farewell dinner in honour of long time All Saints nurse, Von Ryan (Judith McGrath).