Samantha...Who? That's what Sam Newly, irresistibly played by Christina Applegate, would like to know! Upon waking up from an eight-day coma, she can't remember a thing - not her boyfriend, her parents, her job, not even herself. Although some things are best left forgotten, Sam is determined to dig up the "goods" on herself. With a little help from her ex-boyfriend, ex-doorman, her too (make that two) few friends and slightly odd parents, Samantha gets a once-in-a-lifetime opportunity to become a bad-girl-gone-good.