As the Great War breaks out, Ann Vickers (Irene Dunne), a serious, independent, and forthright woman, falls for an officer who jilts her before she can tell him she's pregnant. After an abortion, she throws herself into social work, stirring things up at a women's prison and writing a bestseller about the experience. Back in Manhattan she runs a halfway house for paroled women and meets an equally free-thinking jurist, Barney Dolphin (Walter Huston), who's estranged from his wife (she doesn't believe in divorce) and under investigation for corruption. Ann and he begin an affair and have a child just as he's indicted. Scandal ruins her career. Can they flout convention and find happiness?