The city of Calcutta. A city so vibrant, so alive, so stylish, it was referred to as 'The Paris of the East'. This exotic backdrop serves as the perfect locale for the tender, immortal love story about to unfold. A young girl Lolita (Vidya Balan), orphaned at an early age is sent to live with her Uncle's family, where destiny introduces her to a young boy: Shekhar (Saif Ali Khan), a budding musician, son of an affluent businessman. Together through childhood and adolescence, Shekhar and Lolita share joys and sorrows, fond memories and bittersweet experiences... and unknown to them a relationship of deep friendship and trust takes place. It is an unspoken right they hold over each other that metamorphoses into a love so intense; they do not even see it coming. It takes the arrival of an outsider Girish (Sanjay Dutt) for them to discover their true feelings for each other. The chemistry between Lolita and Shekhar sizzles and sparkles until it explodes. But fate has something else in store for them. Greed, deception and malicious intents are waiting to plague Lolita and Shekhar's deep and innocent love. Events twists and turn beyond their control, spin around them in a maze of misunderstandings and exploding tempers... till even their love cannot stop them from being torn apart. Can true love conquer these insurmountable obstacles, or will it succumb to them? Will Lolita and Shekhar be forever swept apart by these tumultuous events or can they fulfill their destiny and come back together?