Rent Gray Matters (2006)

They finish each other's sentences, dance like Fred and Ginger, and share the same downtown loft - the perfect couple? Not exactly. Gray and Sam (Heather Graham and Tom Cavanagh), are a sister and brother so compatible and inseparable that people actually assume they are dating. Mortified, they both agree they must branch out and start searching for love. He'll look for a guy for her and she'll look for a gal for him. But when Sam finds his perfect mate in Charlie (Bridget Moynahan), Gray's life turns inside out. A charming romance, a tender comedy, the story of Gray's quest to find out who she really is gives a whole new meaning to love and destiny.