It's a whole new world for Waterloo Road as many of the teachers and some of the pupils move to a new academy school in Greenock, Scotland, sponsored by successful businesswoman Lorraine Donnegan.
Grantly and Maggie, soon to be married, are house parents to the kids who have come up from the old school, while Head Teacher Michael Byrne, Sian, Tom, Janeece and Chalky immerse themselves in the new school, pupils both new and old and all the challenges they bring with them.
New teachers include the strait-laced Audrey McFall, and Christine Mulgrew, a semi-functioning alcoholic who wreaks havoc in the lives of all around her. New pupils include Christine's son and primary buffer Conor, who is constantly saved from veering off-track by new girl Imogen. However, even she is fated to fall victim to the dysfunctional Mulgrew mother/son relationship.
With Head Teacher Michael having to face the ghosts of his past, young Scout suffering relentless bullying from new girl Rhiannon, and Tariq facing an uncertain future both physically and emotionally, a new look Waterloo Road gets off to a fiery start, building to a fiery and explosive finish.