At the end of the 19th century, Valentine (Audrey Tautou), 20, from a bourgeois family, married Jules (Arieh Worthalter). She will have with him several children, several happinesses, several dramas. She will have a son who will fall in love with Mathilde (Mélanie Laurent), with whom he will start a family. Around them gravitates Gabrielle (Bérénice Bejo), whom she considers her sister. Over the years, births and deaths, the fate of these three women is emerging.