Jane Seymour resumes the role of Dr Michaela Quinn as she returns to Boston with Sully and family to attend Colleen's graduation from Harvard Medical School. Despite her top grades, Colleen is facing the same prejudice from the Boston medical community as her mother had done before her. Will she ever be accepted by the profession? Meanwhile, as her condition worsens, Michaela's ailing mother continues to fight for her family's dreams. How will it all end?