"Nonnas" follows Joe (Vince Vaughn / Theodore Helm), who, after losing his mom and grandmother, turns to their generations-old recipes for solace and direction. With the money from his mom's insurance and a little help from his friends, he opens Enoteca Maria, an old-school Italian spot staffed by four grandmothers, or "nonnas", from different cities in Italy, who share their dishes with the neighborhood.