George Dumurrier (Jean Sorel) is a wealthy doctor who runs a clinic with his younger brother Henry (Alberto de Mendoza), but leaves care of his asthma-stricken wife Susan (Marisa Mell) to her sister Marta and a local nurse. He is engaged in an affair with Jane, the personal assistant to Larry, a trendy photographer. Although very much in love with George, Jane is fatalistic about the future of their relationship. George and Jane travel out of town for a romantic break in Reno. But after arriving at the casino, George receives a phone call from Henry, telling him that Susan has died during a violent asthma attack. Returning home to his plush San Francisco home, George is consoled by Henry, but frozen out by the hostile Marta, who has always disapproved of George marrying her sister. However, a $1 million insurance policy left by Susan is a timely bonus for George's recklessly extended business enterprise. An insurance agent begins tailing George, discovers his affair with Jane, and brings his suspicions to the local police detective, Inspector Wald.