Thanks to the dragon balls and his dedicated assistant Dr. Kochin, the evil Dr. Wheelo has been freed from his icy tomb. Now these mad scientists plot to take over the world with their fearsome biotechnology - there's just one hitch: Dr. Wheelo's body has died, but now his brain is living in a glass jar! Dr. Wheelo seeks the strongest, healthiest body in the world to be the new home for his magnificent brain, so Dr. Kochin and the android warriors kidnap Piccolo and the master Roshi trying to find the worlds strongest fighter. Goku, Gohan and Krillin come to their friend's rescue, but Dr. Wheelo's henchmen are amazingly strong! To make matters worse, it seems that Dr. Wheelo not only want to have Goku's body, but he already contols Piccolo! Will our heroes save the day or lose their minds?!