Omens and concepts of good vs. evil have no place in Maggie O'Connor's (Kim Basinger) well ordered, practical universe. Her life revolves around her job as a nurse at a busy New York hospital - that is, until her wayward kid sister, Jenna (Angela Bettis), shows up on her doorstep and saddles her with an autistic newborn child, Cody. Cody quickly becomes the daughter she has always longed for, but six years later Jenna suddenly re-enters her life and, with her mysterious new husband, Eric Stark (Rufus Sewell), abducts Cody. Maggie discovers that the child possesses extraordinary powers... powers that forces of evil have waited centuries to control. Together with an FBI specialist in occult-related crimes (Jimmy Smits), Maggie races to save the life of the innocent girl who may hold the keys to save mankind... or destroy it.