The story begins as the Newton household prepare for a cross-country drive to a family reunion. For Richard, the father, it's a dream vacation. For his family it's boredom on wheels – until the appearance of a surprise passenger. Along for the ride is the huge, slobbering and loveable dog, Beethoven who soon unleashes a string of canine calamities! But when two bumbling thieves threaten the safety of the Newtons, it's Beethoven who sets out to put the bite on the bad guys and forever win a place in his new family's hearts.