Former boxing champions Vince (Woody Harrelson) and Caesar (Antonio Banderas) get the chance to finally be a boxing match in Las Vegas, which they can earn a lot of money. They're going to this great challenge, but they need each other! Along with their tough girlfriend Grace (Lolita Davidovich) they cross the desert to get to their destination within 24 hours. Along the way come up old conflicts and shows that both still have a soft spot for Grace. Tensions run high. Vince and Caesar try another so to outdo that the game is not just to win, but maybe even for their friendship!