Deadly mutant rattlesnakes have infested the sleepy Californian Desert Town of San Catalano. These Hybrid killers strike in silence and no one is safe. Vic Rondelli has recently arrived in town to take over as the new fire chief and meets Max Farrington whose construction crews are blasting rock for a new phase of his residential development. It's clear that the appearance of the lethal rattlers has coincided with these explosions. As the killer attacks increase, panic spreads amongst existing residents and they evacuate their homes. Farrington, despite Vic's warnings, is determined to find and destroy the central rattlesnake den.