A young boy, Jeramiah Bridger, witnesses the massacre of his Ma, Pa and Little Sister by Indians. He grows into a vengeful, hate-filled young man (Leondard Mann) killing Indians and selling their scalps. After capturing a beautiful Indian girl, Jeremiah falls foul of two of local businesman Pertins' (Ivan Rassimov) henchmen. Shot and bleeding Jeremiah is saved and healed by travelling quack Doc (Steffen Zacharias) who also informs him that Indians didn't murder his family but Perk's men did. With help of rabble rousing journalist Prescott (Klaus Kinski) and white men dressed as Indians, at last Jeremiah has in his sights the man responsible for his family's death. He really is on the Vengeance Trail and no-one better get in his way!