When multiple bombs incite terror in Las Vegas, the shockwaves reach far and wide. Former CSI head Gil Grissom (William Petersen) responds to the call of duty. FBI Agent Catherine Willows (Marg Helgenberaer) rushes back to her old hunting grounds, ana former LVPD Capt. Jim Brass (Paul Guilfoyle) finds his way to the crime scene. In his final Vegas case, lead investigator D.B. Russell (Emmy winner Ted Denson) helps unravel the fiendish web of evidence. The case turns personal as seasoned pro Sara Sidle (Jorja Fox) navigates her history with Grissom. Then the team itself becomes a target, forcing the elite experts of CSI (Eric Szmanda, Robert David Hall, Wallace Langham, David Berman, Elisabeth Harnois, and Jon Wellner) to outrace an explosive threat to Sin City. Only Grissom's femme fatale Lady Heather (Melinda Clarke) holds the deadly key to the secrets in this epic finale that changes everything.