His Majesty was all powerful and all knowing. But he wasn't quite all there. 1788 - King George IIl (Nigel Hawthorne) is almost 30 years into his reign and is once again preparing for the Opening of Parliament. Queen Charlotte (Helen Mirren) skillfully divides her role as both devoted wife and mother to their 15 children. Yet, despite the apparent veneer of respectability, something is going sadly awry within the walls of Windsor Castle. The King's behaviour is becoming increasingly irrational, he is babbling ceaselessly, spewing obscenities and attacking the Queen's Mistress of Robes, Lady Pembroke (Amanda Donohoe). Has the King of England gone...mad? As the King's condition deteriorates, his son, the Prince of Wales (Rupert Everett) sets out to have his father declared unfit in order that he should be proclaimed Regent. The Queen is denied access to her husband and the King consequently becomes an isolated figure at the mercy of his own inept physicians. Not until he is persuaded to engage a new doctor, Dr Willis (Ian Holm) does the King show any signs of improvement. Yet the King's only true salvation relies on the support of the most potent of medicines - the Queen herself.