The series takes viewers to the epicenter of America's struggle with opioid addiction, from the boardrooms of Purdue Pharma, to a distressed Virginia mining community, to the hallways of the DEA...Richard Sackler (Michael Stuhlbarg) begins to launch a powerful new painkiller, a rural doctor is introduced to the drug, a coal miner plans her future, a DEA agent learns of black market pills and federal prosecutors decide to open a case into OxyContin...Doctor Finnix (Michael Keaton) begins to take Betsy (Kaitlyn Dever) off OxyContin, Bridget (Rosario Dawson) sees the toll the it's taking on communities, Rick (Peter Sarsgaard) and Randy (John Hoogenakker) investigate the world of "pain societies" and, with sales climbing, Richard Sackler makes bigger plans for his new drug...Rick and Randy's criminal investigation now threatens Richard Sackler's empire, activists take action against Purdue, and Finnix tries to heal his beloved community that's been ravaged by addiction...
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