Spirals are everywhere. From snail shells to washing machines, to fingertips, to the insides of our ears. Wherever you look, a spiral isn't far away. But in the sleepy town of Kurouzucho long-time friends Kirie and Shuichi have discovered how deadly spirals can be. A spiral-obsessed man commits suicide in a washing machine, leaving his body contorted into a spiral. A young student falls to his death down a spiral staircase. A women becomes so afraid of the spirals on her fingerprints that she cuts off her own fingertips. One by one, the people of Kurouzucho are twisted, mentally and physically, as reality itself begins to distort into a horrific vortex. Humanity begins to transform into snail like beings in spiral shaped shells as Uzumaki, the power of the Vortex, takes control. With the sky above turning to nightmare patterns of whirls, is there any way that Kirie and her boyfriend can escape?