Everything seems to divide Sara, (Salma Hayek) the daughter of a rich banker, and Maria, (Penelope Cruz) raised in a family of poor farmers. Until Tyler Jackson, a representative of the New York Bank and Trust, unites them in tragedy, devastating both women's families in order to take illegal control of Mexican lands in the name of the expansion of the U.S. railroad. Determined to avenge the attacks on their fathers and protect the peasants' lands, Sara and Maria become daring bank robbers, holding up every Bank and Trust subsidiary in the region. Sent to the scene to arrest the young women, Quentin, a novice police inspector, is soon won over to the cause of the two beautiful vigilantes. Meanwhile, Jackson and his men learn to fear the guns of those who become known throughout the country as the "Bandidas".