The story centres on John Joseph McCann (Jo Jo), a thief with attitude, and those nearest and dearest to him: Lorraine a would be Marilyn Monroe look-alike who falls in love with him; and Clare, his sharp young lawyer. Jo Jo's love of crime started when he was a child, when he pilfered cash boxes for his father. He's been in and out of prison ever since. He lives in a housing estate with his mother and sister at a time when, virtually overnight, hard drugs followed by AIDS arrive in housing estates across the UK. As drug dealing becomes rife in the city, Jo Jo is tempted into a new line of business. Set against a backdrop of events which defined the early 1980s 'Looking After Jo Jo' is the compelling story of one man's struggle to survive.