The substitute returns to the classroom to teach a new lesson. Foul play is controlling the Eastern Atlantic University campus. If the starting line-up doesn't make the grade, the winning football season will be in jeopardy, and one professor refuses to play by the rules. After Professor Nicole Potter is brutally attacked, Karl Thomasson (Treat Williams) goes undercover once again to bring the attackers to justice. Thomasson and his crew of mercenaries soon discover the football team is using their muscle off the playing field as well. The players are deep into a dangerous underworld of blackmail and drugs to ensure their victory. Before class is dismissed, the Substitute will have to teach these students a lesson they will never forget.