When archaeologist Anna (Gina Philips) stumbles across an ancient relic in a disused London hospital, she believes she can save the crumbling structure - and her year's work - from imminent destruction. Meanwhile, after being involved in a fatal hit-and-run accident, a group of terrified teenagers take refuge in one of the hospital's old wards... Determined to prove the relic's worth, Anna opens it but unwittingly releases the evil spirit of a doctor who once treated plague victims at the site. With both Anna and the teenagers trapped, this malevolent force can once again bring pain and suffering to those he is meant to help. One by one they all encounter the Doctor's evil reincarnation and find themselves fighting for their lives - and souls – in a long-forgotten medieval underworld.