It has become all-out war between humanity and the 'Parasites' - the tiny creatures who are rapidly taking over the brains of the human populace. But nothing is black and white in this struggle. Why have the Parasites come to Earth? Are they here to cull our numbers? The planet may be better off preserved from the destructive nature of humanity, but we also want to fight to protect our loved ones. Amidst this conflict of values, Shinichi and Migi, who became stuck in Shinichi's hand after failing to take over his brain, must continue to work together in the escalating fight against the Parasites.