Two sister's lifelong struggle with mental illness, daily hardships and their own conflicted relationship evolves into mutual respect and understanding in this poignant and emotional real life story. Throughout their life, Christine (Kathy Bates) and Judy's (Elizabeth Perkins) stern but dutiful, devoted mother tries to hide the fact that Christine is not like other girls. Suffering from Schizoaffective Disorder, Christine is in and out of hospital for most of her teenage years leaving her younger sister Judy confused and ambivalent to someone who her mother loves as dearly as her. In later life, Judy, who has escaped the confines of small town life to New York, receives a visit from her sister. But the re-acquaintance turns sour when Judy's friend begins displaying the kind of prejudice Christine and Judy's mother attempted to protect them from during childhood. And when their mother succumbs to a debilitating illness, Christine's need for her sister becomes more apparent and overwhelming. Judy fears she must finally confront her own inability to form relationships, and reconcile her feelings towards her sister so that they can both begin to lead the normal, loving lives they crave so much.