Marlene Dietrich stars as Helen, a former nightclub entertainer married to an American scientist, Edward Faraday (Herbert Marshall), who has been diagnosed with radium poisoning. To earn money for her husband's European cure, Helen returns to the stage billed as "The Blonde Venus" and is an overnight success. She also finds herself powerfully attracted to a dashing politician named Nick Townsend (Cary Grant) who is captivated by her and offers financial support. Townsend moves Helen and her son into a beautiful apartment, and when Edward returns unexpectedly from Europe to find his child and unfaithful wife gone, he demands she relinquish the boy to him. As a woman torn between her husband, her lover, her career and her child, Dietrich turns in a dazzling performance that makes this one of the screen goddess's most popular films.