A raucous comedy set in Victorian London about four medical pioneers, friends and rivals - fighting to make a mark on the world. The 1840s was a time when doctors were just as likely to kill their patients as cure them, when the medicine that we take for granted today was in its infancy, and when doctors experimented on themselves and each other. It's an era when dentists numbed the pain with brandy, the insane were chained up, and the operating theatre was full of spectacle and showmanship where people would come to watch a surgeon beat his amputation speed record. Robert (Rory Kinnear) is an extraordinary, ambitious showman surgeon who can take a leg off in 92 seconds. William (Mathew Baynton) is a nervous, kind psychiatrist (then called alienist) looking to transform mental care. John (Tom Basden) is a wild, hedonistic, dentist turned anaesthetist. Caroline (Lydia Leonard) is the headstrong, intelligent wife of Robert, who is determined to fight against the male prejudices and patriarchy of Victorian society to realise her own medical ambition. Finally, there's Dr Hendrick (Rupert Everett) - The Royal Physician. He hates innovation and young people. And women. And patients.