A 40-ton truck is a lethal weapon and veteran driver Jack Crews (Patrick Swayze) knows how to use it. Desperate for cash, he's got one last delivery to make. The trip's barely begun when he and partner Earl (Randy Travis) discover they've been set up and are being chased by Red (Meat Loaf), a relentless fanatic who's as deadly as he is greedy.
Now, with his family, his life and his freedom on the line, Jack's going to buckle up, put the pedal down and show Red and the Feds a thing or two about road rage. After being double-crossed and rudely underestimated, Jack and Earl shift gears, becoming a two-man wrecking crew, trucking down the highway blazing a trail of diesel-powered destruction.